The concept of sickness behavior: a brief chronological account of four key discoveries

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

Life Sciences, Genetics, Immunology +15

Murine tumor necrosis factor alpha is transported from blood to brain in the mouse

Enrique G. Gutierrez, William A. Banks, Abba J. Kastin · Journal of Neuroimmunology · 1993 · 578 citations

Life Sciences, Neurobiology, Neuroscience +10

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

Sophie Layé, Patricia Parnet, Emmanuelle Goujon et al. · Molecular Brain Research · 1994 · 497 citations

Life Sciences, Immunology, Neuroscience +16

Fever and Survival

Matthew J. Kluger, Daniel H. Ringler, Miriam R. Anver · Science · 1975 · 493 citations

Life Sciences, Microbiology, Physiology +17

Penetration of interleukin-6 across the murine blood-brain barrier

William A. Banks, Abba J. Kastin, Enrique G. Gutierrez · Neuroscience Letters · 1994 · 488 citations

Life Sciences, Neuroscience, Pharmacology +12