Benzpyrene Hydroxylase Induction by Polycyclic Hydrocarbons in Hamster Embryonic Cells Grown in vitro

Abstract

Treatment of hamster embryonic cells with 1,2-benzanthracene for 4 to 48 hours induced a three- to tenfold increase in the activity of benzpyrene hydroxylase. That the increase in enzyme activity was completely prevented by puromycin suggested an induction of enzyme synthesis.