Ergosterol biosynthesis inhibitors. An overview of their history and contribution to medicine and agriculture

Abstract

Abstract Over the past 15 years, an increasing number of ergosterol biosynthesis inhibitors (EBIs) have been introduced in crop protection as fungicides, and in medicine as fungicides and bactericides. Their spectrum of activity and their systemic properties vary widely, depending on structural elements. By their high protective and curative activity the EBIs have greatly improved the level of disease control, both in plants and in man. However, the chemical and biological potential of this group has not yet been fully explored, particularly in the field of growth regulation.