Troglitazone‐induced intracellular oxidative stress in rat hepatoma cells: A flow cytometric assessment

Abstract

Multiparameter flow cytometric evaluation of N1S1 cells indicated that the chromane ring of TRO, rather than the TZD moiety, may be responsible for oxidative stress and suggested that a direct effect on mitochondrial physiology may play a role in TRO-mediated hepatotoxicity.