Indian journal of radiology and imaging - new series/Indian journal of radiology and imaging/Indian Journal of Radiology & Imaging · 2002 · 25 citations · 0 references
Open access
MedicineOncologyRadiation OncologyClinical Radiation OncologyPain ManagementRadiobiologyBone Metastasis PainBone Metastasis PalliationPalliative RadiotherapyRadiation TherapyRadiation Therapy For Pain ReliefRadiation ToxicityBone Metastases ManagementBone Pain PalliationExternal Beam Radiation CarePalliative Radiotherapy ResponsePalliative Radiotherapy ToxicityRadiotherapy For Bone MetastasesRadiotherapy-associated Pain ReliefSingle-fraction Treatment
Objective: This prospective study was done to compare the role of the multi fraction (MF) and single fraction (SF) radiotherapy in the management of bone secondaries as regards potency for pain relief and resultant early toxicities. Materials and Methods: Seventy three out of eight five patients with bone metastases, who fulfilled the inclusion criteria were randomly divided into two groups to be treated by External radiation either by 3000 cGy over 2 weeks in 10 Fractions i.e. multiple fraction (MF) or by 8000 cGy in single fraction (SF). Pre and Post radiation pain relief potential and early toxicities due to the treatment were compared. Results: No significant difference (P>0.50) was observed as regards pain relief which was 84% in Gr-I (MF) and 76% in Gr - II (SF). Similarly incidence of complete pain relief, (42% VS - 35%) no response (16% VS 24%) and early toxicities also show marginal difference. Conclusion: Though both the radiation schedules resulted in considerable reduction of Bone pain in majority of the patients, no significant difference was observed as regards pain relief and early toxicities.