Adsorptive Depletion of Elevated Proinflammatory CD14⁺CD16⁺DR⁺⁺Monocytes in Patients With Inflammatory Bowel Disease

Abstract

A significant reduction in peripheral CD14(+)CD16(+) monocytes by GMA should mitigate the inflammatory drive and contribute to the clinical efficacy of this procedure. Reduction of CD14(+)CD16(+) monocytes by corticosteroids was also seen. Hence, corticosteroids should enhance the efficacy of GMA. This is the first report on CD14(+)CD16(+) monocytes being decreased by Adacolumn GMA in patients with IBD.