Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca<sup>2+</sup> Homeostasis and Preventing Calpain Activation

Abstract

These findings suggest that berbamine confers cardioprotection against I/R injury by attenuating [Ca(2+)inf(i) overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoK(ATP) channel.