Organic Letters · 2011 · 68 citations · 41 references
Natural SciencesChemistryCatalysisGreen ChemistryOrganic ChemistryCatalytic MaterialsCatalytic MechanismsGreen CatalysisMicrowave-assisted SynthesisOrganic SynthesisSolvent-free SynthesisAlkylation CatalysisAlkylation ProcessesAlkylation ReactionsMicrowave-assisted AlkylationMicrowave-assisted CatalysisMicrowave-assisted Condensation ReactionsMicrowave-assisted Green SynthesisMicrowave-assisted Organic Synthesis
Microwave-assisted iridium catalyzed alkylation of amines with alcohols was undertaken under solvent-free and base-free conditions. Such alkylation reactions are green, atom-economic, and effective for mono-, di-, and triaklyation of amines. Good isolated yields were obtained for mono- and dialkylated amines using stoichiometric amounts of amines and alcohols, in the presence of 1 mol % [Cp*IrCl(2)](2). Reasonable yields of trialkylated products were obtained using 4 equiv of alcohols.
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