Concepedia

Highly Enantioselective Hydrogenative Desymmetrization of Bicyclic Imides Leading to Multiply Functionalized Chiral Cyclic Compounds

Masato Ito, Chika Kobayashi, A. Himizu, Takao Ikariya

Journal of the American Chemical Society · 2010 · 79 citations · 45 references

DOI

Concepts

Abstract

Highly enantioselective hydrogenative desymmetrization of bicyclic imides has been developed with chiral Cp*Ru(PN) catalysts. The present hydrogenation directly provides stereochemically well-defined cyclic compounds with excellent enantiomeric exessses, which might otherwise require a detour to reach.

References

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