Interleukin‐1β increases RANTES gene expression and production in synovial fibroblasts from human temporomandibular joint

Abstract

The RANTES, a cc-type chemokine, has chemotactic effects on lymphocytes and monocytes. Increased gene expression and protein production of RANTES in synovial fibroblasts, in response to IL-1beta, may play an important role in recruitment of inflammatory cells into synovium and progression of synovitis in TMD.