Effect of Thymol on Ca<sup>2+</sup> Homeostasis and Viability in MG63 Human Osteosarcoma Cells

Abstract

In MG63 cells, thymol induced a [Ca(2+)](i) rise by inducing phospholipase C-dependent Ca(2+) release from the endoplasmic reticulum and Ca(2+) entry via protein kinase C-sensitive store-operated Ca(2+) channels. Thymol induced cell death that may involve apoptosis via mitochondrial pathways.