Contribution of H3K4 methylation by SET‐1A to interleukin‐1–induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes

Abstract

These results indicate that H3K4 methylation by SET-1A contributes to IL-1-induced iNOS and COX-2 expression and suggest that this pathway could be a potential target for pharmacologic intervention in the treatment of OA and possibly other arthritic diseases.