New Macrodiolide Antibiotics, 11-<i>O</i>-Monomethyl- and 11,11‘-<i>O</i>-Dimethylelaiophylins, from <i>Streptomyces</i> sp. HKI-0113 and HKI-0114

Abstract

Elaiophylin (1) and two new methyl derivatives, 11-O-monomethylelaiophylin (2) and 11,11‘-O-dimethylelaiophylin (3), were isolated from the mycelium cake of Streptomyces strains HKI-0113 and HKI-0114. The structures of 2 and 3 were determined by mass spectrometric and NMR investigations. Compounds 2 and 3 display antimicrobial and moderate cytotoxic activities.