Vascularized Lymph Node Transplantation Induces Graft-Versus-Host Disease in Chimeric Hosts

Abstract

When introducing allogeneic cells into chimeric recipients, concomitant transplantation of the vascularized LN microenvironment makes a manifest difference between induction and absence of GVHD. This illustrates the important role of the LN microenvironment in adaptive immune responses.