Cytopathic effect of botulinum C₂toxin on tissue-culture cells

Abstract

Botulinum C2 toxin, which has enterotoxic as well as lethal activities, induced roundings of tissue-cultured cells of eight different mammalian cell lines. The morphological changes in all of the cell lines were accompanied by degeneration and lysis of cells. The results indicate that C2 toxin has cytopathic activity and causes cytotoxic effect on mammalian cell lines.