Concepedia

Serotonin Depletion, Cortical Spreading Depression, and Trigeminal Nociception

Weera Supornsilpchai, Sompol Sanguanrangsirikul, Supang Maneesri, Anan Srikiatkhachorn

Headache The Journal of Head and Face Pain · 2006 · 99 citations · 14 references

DOI

Abstract

Our findings indicate that 5-HT depletion enhances CSD-induced trigeminal nociception by increasing the cortical excitability and sensitivity of trigeminal nociceptive system. These findings may provide a better understanding regarding the relationship between low 5-HT and clinical headaches.

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