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Effect of Copper Applied Topically or in Drinking Water on Experimental Caries in Rats

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1984

Year

Abstract

The effect of copper sulfate applied topically or in drinking water on dental caries was investigated in rats. Two daily topical applications of 0.2 ml of 5.0 mM Cu2+ as CuSO4 ad libitum or 1.0 mM CuSO4 in the drinking water reduced the caries scores significantly on all tooth surfaces. The number of Streptococcus mutans colonising tooth surfaces was also significantly reduced by 1.0 mM Cu2+ in drinking water.