Highly Regioselective Palladium-Catalyzed Oxidative Coupling of Indolizines and Vinylarenes via C−H Bond Cleavage

Abstract

A highly regioselective oxidative coupling reaction between indolizines and vinylarenes has been accomplished in the presence of palladium catalysts to give only the branched α-product in high efficiency. The regioselectivity is promoted significantly by bidentate nitrogen ligands.