PANETH CELL GRANULE OF MOUSE INTESTINE

Abstract

The Paneth cell secretion of the mouse intestine has been reported to be an acid mucopolysaccharide-protein complex; tryptophan as well as alpha acylamido carboxyl, amino, and phenolic groups of protein have been localized to the characteristic granules by means of histochemical staining procedures (13). Sulfhydryl and disulfide groups of protein have also been localized to the granule (14). The protein nature of the granule was suggested earlier by Hintzche and Anderegg (5). Hally (3) concluded that the uttrastructure of the Paneth cell was typical of an exocrine, serozymogenic cell, and suggested that the secretory granule arose within the Golgi complex. It was This investigation was supported by research grant