Using thrombolytics in frostbite injury

Abstract

Until recently, the treatment of frostbite injuries has been limited to supportive care only, with mediocre outcomes. The use of thrombolytic therapy has been presented in a limited fashion in the literature since 2005. This case study describes the work-up and treatment of a patient with severe frostbite injury who received tPA. We then discuss thrombolytic therapy in more detail, with particular attention to the two studies outlining different treatment regimens.