SYNTHESIS AND CHARACTERIZATION OF ANTIBACTERIAL Co(II), Cu(II), Ni(II), AND Zn(II) COMPLEXES OF ACYLHYDRAZINE DERIVED PYRROLYL COMPOUNDS

Abstract

ABSTRACT Acylhydrazine derived pyrrolyl ligands and their metal [Co(II), Cu(II), Ni(II), and Zn(II)] complexes have been prepared and characterized on the basis of elemental analyses, magnetic moments, molar conductances and spectroscopic (electronic, IR, 1H and 13C NMR) data. All of these compounds function as tridentate ligands, with their deprotonated enolic form being preferred in the coordination to the metal ions. The title synthesized ligands and their metal(II) complexes have been screened for bactericidal activity against the pathogenic bacterial species Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, and it is shown that the metal complexes act as more active antibacterial agents than the uncomplexed ligands from which they derive. ACKNOWLEDGMENT The authors acknowledge the help of the Department of Microbiology, Qaid-e-Azam Medical College, Bahawalpur, in undertaking the antibacterial studies.