NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts

Abstract

Ang II-evoked expression of ET-1 in adventitial fibroblasts appears to be mediated, at least in part, by NADPH oxidase. Functionally, this mechanism stimulates collagen expression thereby implicating the adventitia as a potential contributor to the vascular pathophysiology associated with oxidative stress and vascular remodeling.