Publication | Closed Access
Reaction of silyl ketene acetals with N-trimethylsilyl imines: a route to N-unsubstituted azetidin-2-ones
44
Citations
0
References
1985
Year
PharmacologyN-trimethylsilyl IminesN-unsubstituted Azetidin-2-onesIntermediate N-silyl β-AminoestersOrganic ChemistryChemistryHeterocycle ChemistrySilyl Ketene AcetalsPharmaceutical ChemistrySynthetic ChemistryEnantioselective Synthesis
Reaction of N-trimethylsilyl imines with silyl ketene acetals in the presence of ZnI2 and t-butyl alcohol, followed by treatment in situ of the intermediate N-silyl β-aminoesters with MeMgBr, leads to N-unsubstituted azetidin-2-ones in good yield.