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Combined thiazolidinedione–metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle

N. Temofonte, Mini P. Sajan, Sonali Nimal, Tina E. Pastoor, Carlos Fumero, Leanne K. Casaubon, J. L. Powe, Mary L. Standaert, Robert V. Farese

Diabetologia · 2008 · 15 citations · 11 references

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References

11

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

Laurie J. Goodyear, Francesco Giorgino, L. Sherman et al. · Journal of Clinical Investigation · 1995 · 525 citations · Full text

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Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

Young‐Bum Kim, Svetlana E. Nikoulina, Theodore P. Ciaraldi et al. · Journal of Clinical Investigation · 1999 · 491 citations · Full text

, , +17

Insulin-Stimulated Phosphorylation of the Akt Substrate AS160 Is Impaired in Skeletal Muscle of Type 2 Diabetic Subjects

Håkan Karlsson, Juleen R. Zierath, Susan E. Kane et al. · Diabetes · 2005 · 309 citations · Full text

, , +17

Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM Subjects

Anna Krook, Richard A. Roth, Xin Jiang et al. · Diabetes · 1998 · 296 citations

, , +16

Defective Signaling Through Akt-2 and -3 But Not Akt-1 in Insulin-Resistant Human Skeletal Muscle

Joseph T. Brozinick, Brian R. Roberts, G. Lynis Dohm · Diabetes · 2003 · 168 citations · Full text

, , +17