Erythema and Desquamation After High-Dose Methotrexate

Abstract

Brief Reports1 May 1983Erythema and Desquamation After High-Dose MethotrexateL. AUSTIN DOYLE, M.D., CHRISTINE BERG, M.D., GINO BOTTINO, M.D., BRUCE CHABNER, M.D.L. AUSTIN DOYLE, M.D.Search for more papers by this author, CHRISTINE BERG, M.D.Search for more papers by this author, GINO BOTTINO, M.D.Search for more papers by this author, BRUCE CHABNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-611 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn erythematous, desquamating rash of the hands developed in three patients with non-Hodgkin's lymphoma after treatment with high-dose methotrexate. The patients received methotrexate on ProMACE combination chemotherapy (1): cyclophosphamide, 650 mg/m2· body surface area; doxorubicin, 25 mg/m2; and VP-16-213, 120 mg/m2, all intravenously on days 1 and 8; plus prednisone, 60 mg/m2orally days 1 through 14, and methotrexate, 1. 5 grams/m2intravenously on day 14. The methotrexate was followed after 24 hours by folinic acid, 50 mg/m2intravenously every 6 hours, until methotrexate levels less than 5 X 10-7M were recorded. Each cycle took 28 days. After...References1. FISHERDEVITAHUBBARD RVS. Diffuse aggressive lymphomas: increased survival after alternating flexible sequences of ProMACE and MOPP chemotherapy. Ann Intern Med. 1983;98:304-9. LinkGoogle Scholar2. DEVITASERPICKCARBONE VAP. Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med. 1970;73:881-95. LinkGoogle Scholar3. RODBARD D. The role of regional body temperature in the pathogenesis of disease. N Engl J Med. 1982;305:808-14. Google Scholar4. KARUSH F. Immunological specificity and molecular structure. Adv Immunol. 1962;2:1-40. Google Scholar5. FRANKGAITHER MT. The effect of temperature on the reactivity of guinea-pig complement with ᵧG and ᵧM haemolytic antibodies. Immunology. 1970;19:967-74. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. AUSTIN DOYLE, M.D.; CHRISTINE BERG, M.D.; GINO BOTTINO, M.D.; BRUCE CHABNER, M.D.Affiliations: National Cancer Institute-Navy Medical Oncology Branch Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFolate AntagonistsOral Ulceration and Skin Eruption After a High Dose of MTXCutaneous toxicity of oral low-dose methotrexateMethotrexateMethotrexateMethotrexate Toxicity During Treatment of Chronic Plaque Psoriasis: A Case Report and Review of the LiteratureAn update on pediatric cutaneous drug eruptionsFolate AntagonistsDrug ReactionsToxic erythema of chemotherapy: A useful clinical termAcral Erythema with Oral Methotrexate in a ChildHand-Foot Syndrome Variant in a Dihydropyrimidine Dehydrogenase–Deficient Patient Treated with CapecitabineClinical utility and pharmacology of high-dose methotrexate in the treatment of primary CNS lymphomaVascular Toxicity of Antineoplastic AgentsMethotrexate-induced bullous acral erythema in a childNormal-looking skin in oncohaematological patients after allogenic bone marrow transplantation is not normalA Case of Docetaxel-Induced ErythrodysesthesiaPalmar-plantar erythrodysesthesiaClofarabine-induced Acral Erythema During the Treatment of Patients with Myelodysplasia and Acute Leukemia: Report of Two CasesBullous Acral Erythema Secondary to High-Dose MethotrexateRadiation Recall Dermatitis Induced by Methotrexate in a Patient With Hodgkin’s DiseasePalmar-Plantar Erythrodysesthesia Syndrome Associated with Liposomal DaunorubicinToxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazoleAntineoplastic Therapy???Induced Palmar Plantar Erythrodysesthesia (???Hand-Foot???) 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LOKICH, M.D., CHERYL MOORE, R.N.The Pharmacology and Clinical Use of Methotrexate 1 May 1983Volume 98, Issue 5_Part_1Page: 611-612KeywordsBody surface areaCombination chemotherapyCyclophosphamideDesquamationErythemaLymphomaMethotrexateRashes ePublished: 1 December 2008 Issue Published: 1 May 1983 PDF downloadLoading ...