Regioselective Synthesis of Diltiazem Analogue Pyrazolo[4,3-c][1,5]benzothiazepines and Antifungal Activity

Abstract

Abstract A dry media procedure has been developed for the synthesis of a series of new class of pyrazolo [4,3-c][1,5]benzothiazepines 6 under microwave irradiation using montmorillonite K10 as solid support. The catalyst can be recovered and reused. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions. Antifungal screening of synthesized compounds has shown promising activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Keywords: Microwavesmontmorillonitepyrazolo-benzothiazepines Acknowledgments CSIR and U.G.C. New Delhi are gratefully acknowledged. R.S. is thankful to CSIR for the award of a Research Associateship. We are also thankful to RSIC, CDRI, Lucknow, for the elemental and spectral analyses. Notes a Final temperature is measured at the end of microwave irradiation by introducing a glass thermometer into the reaction mixture in the beaker. b The reaction mixture was placed in a preheated oil bath. a Yield of the isolated products. b Using solvent system benzene:ethylacetate (8:2).