Fabrication and Physical Properties of Gelatin/Sodium Alginate/Hyaluronic Acid Composite Wound Dressing Hydrogel

Abstract

Gelatin (Gel), sodium alginate (SA) and hyaluronic acid (HA) based various hydrogels for biomedical applications were prepared by freezing-drying method using 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) as a crosslinker. The physical properties including morphology, water vapor transmission rate and hydrophilicity were investigated. The result showed the Gel/SA/HA composite hydrogels were successfully crosslinked by the crosslinking agent. All the Gel/SA/HA composite hydrogels with different compositions had highly homogeneous and interconnected pores, and the compositions had no significant effect on the surface and cross-section morphologies of the Gel/SA/HA hydrogels. The incorporation of sodium alginate enhanced the water vapor transmission capacity of the hydrogel; however, there were no significant differences between the water vapor transmission rates of all the Gel/SA/HA hydrogels. Gelatin had a low hydrophilic behavior, while sodium alginate exhibited relatively high hydrophilic behavior. The results indicate that the Gel/SA/HA hydrogel cross-linked via EDC is a potential wound dressing material capable of the adequate provision of moist environment for comfortable wound healing.