Concepedia

The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies

Matthew C. Franklin, Elizabeth Navarro, Yujie Wang, Sheetal Patel, Pinki Singh, Yi Zhang, Kris Persaud, Amtul Bari, Heather Griffith, Leyi Shen,

Structure · 2011 · 54 citations · 33 references

Open access

Concepts

PharmacyMolecular BiologyOncologyCell SignalingMonoclonal AntibodiesStructural BiologyAngiogenesisAntibody CharacterizationAntibody FunctionAntibody StructureGrowth Factor SignalingTherapeutic Antibody DevelopmentGrowth Factor-receptor InteractionsStructural Basis Of SpecificityVascular Endothelial Growth Factor Receptor SignalingVegfr Inhibitors

References

33

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

Natural Sciences, Chemistry, Computational Chemistry +16

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

Garib N. Murshudov, A. A. Vagin, E. J. Dodson · Acta Crystallographica Section D Biological Crystallography · 1997 · 14.9K citations

Life Sciences, Biochemistry, Biophysics +13

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

Herbert I. Hurwitz, Louis Fehrenbacher, William Novotny et al. · New England Journal of Medicine · 2004 · 11K citations · Full text

Medicine, Oncology, Pharmacology +15

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

Medicine, Oncology, Pharmacology +17

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

Fouad Shalaby, Janet Rossant, Terry P. Yamaguchi et al. · Nature · 1995 · 3.9K citations

Medicine, Cell Biology, Pathology +8