International Archives of Allergy and Applied Immunology · 2009 · 25 citations · 0 references
Life SciencesImmunologyInfectious DiseasesHypersensitivityImmunology Of Infectious DiseasesImmunopathologyCell-mediated ImmunityCellular Immunity In InfectionCytotoxic T Lymphocyte ResponsesImmunopathology Of Parasitic DiseasePlatelet PhysiologyT Cell BiologyCytotoxic T Lymphocyte FunctionFilariasis PathologyImmunopathology Of FilariasisImmunopathology Of Fungal InfectionsMicrofilarial InfectionsT Cell-mediated CytotoxicityT Cell-mediated Pathology
Platelets isolated from patients infected with filariasis were cytotoxic for microfilariae in vitro. Moreover, platelets from normal donors acquired killing properties in the presence of serum from infected individuals. The humoral factor involved in this cytotoxic process was shown to be IgE. This IgE-dependent cytotoxicity of platelets was strongly inhibited by antigen-stimulated T lymphocyte supernatants from filarial patients.