Evidence for Consistent Intragenic and Intergenic Interactions between SNP Effects in the <i>APOA1/C3/A4/A5</i> Gene Cluster

Abstract

Our analyses suggest that ignoring the contribution of interactions between SNP genotype effects when modeling multi-SNP genotype-phenotype relationships may result in an underestimate of the contribution of genetic variation to variation in quantitative cardiovascular disease (CVD) risk factor traits.