Syntheses, Structures, and Insulin-like Activities of Two Vanadyl Complexes; [VO(GeG)(H2O)] and [VO(MeM)(H2O)]

Abstract

Abstract We prepared [VO(GeG)(H2O)] and [VO(MeM)(H2O)] by a reaction of VOSO4 with GeG and MeM. X-ray analyses of the complexes showed that a tetradentate ligand (GeG or MeM), an oxygen atom, and a water molecule were coordinated with the vanadium(IV) ion forming distorted octahedral geometries. In in vitro evaluation using isolated rat adipocytes, VO(GeG) (IC50=0.42 mM) was found to be more active at lower concentrations than VO(MeM)(IC50=17.0 mM) and VOSO4 (IC50=6.0 mM) in terms of IC50 values, 50% inhibition concentration of the FFA release from adipocytes.