The Immunomodulatory Effects of Hypertonic Saline Resuscitation in Patients Sustaining Traumatic Hemorrhagic Shock

Abstract

This first human trial evaluating the immunologic/anti-inflammatory effects of hypertonic resuscitation in trauma patients demonstrates that HSD promotes a more balanced inflammatory response to hemorrhagic shock, raising the possibility that similar to experimental models, HSD might also attenuate post-trauma MOD.