The First Continuous Flow Hydrogenation of Amides to Amines

Abstract

Hydrogen goes with the flow: Conversion of amides into amines is usually achieved with stoichiometric amounts of metal hydrides, which generate large amounts of waste. Catalytic hydrogenation represents an environmentally benign alternative for this conversion, whereas flow catalysis allows catalyst separation and high throughput. Here, we combine amide hydrogenation and flow catalysis for the first time. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.