Concepedia

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The Effect of Indomethacin on Kidney Function and Plasma Renin Activity in Man

DOI

259

Citations

0

References

1976

Year

A. J. M. Donker, L. Arisz, J. R. H. Brentjens, G.K. van der Hem, H.J.G. Hollemans
Nephron

Abstract

125Iothalamate and 131I-hippuran clearances, sodium excretion and plasma renin activity (PRA) before and during indomethacin administration in an oral dose of 3 x 50 mg/day were studied in volunteers with a normal or reduced kidney function, as well on non-sodium-restricted as on sodium-restricted diet. Indomethacin induced a temporary sodium and water retention and a decrease in glomerular filtration rate. It also lowered PRA. The latter phenomenon did not depend on sodium retention and was present within 2 h after an oral dose of 50 mg. The results may be explained by indomethacin-induced inhibition of prostaglandin synthesis.