Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21^WAF1 and G₁ cell cycle arrest

Abstract

Our results indicate that TSA is able to inhibit bladder cancer cell growth in vitro, possibly through p21WAF1 mediated cell cycle arrest and apoptotic cell death. This study suggests that TSA may be a potential therapeutic agent for the treatment of bladder cancer.