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From Pyrone to Thiopyrone Ligands−Rendering Maltol-Derived Ruthenium(II)−Arene Complexes That Are Anticancer Active in Vitro

Wolfgang Kandioller, Christian G. Hartinger, Alexey A. Nazarov, Maxim L. Kuznetsov, R.O. John, Caroline Bartel, Michael A. Jakupec, Vladimir B. Arion, Bernhard K. Keppler

Organometallics · 2009 · 91 citations · 13 references

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Abstract

Ru(II)−arene complexes with pyrone-derived ligands are rendered active against cancer cells by replacement of the coordinated O,O donor with an S,O donor. The different stabilities of these systems may explain the observed influence of the donor atoms on the anticancer activity in vitro.

References

13

Classical and Non‐Classical Ruthenium‐Based Anticancer Drugs: Towards Targeted Chemotherapy

Wee Han Ang, Paul J. Dyson · European Journal of Inorganic Chemistry · 2006 · 621 citations · Full text

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Structure−Activity Relationships for NAMI-A-type Complexes (HL)[<i>trans</i>-RuCl<sub>4</sub>L(<i>S</i>-dmso)ruthenate(III)] (L = Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl-1,2,4-triazole):  Aquation, Redox Properties, Protein Binding, and Antiproliferative Activity

Michael Groessl, Erwin Reisner, Christian G. Hartinger et al. · Journal of Medicinal Chemistry · 2007 · 212 citations

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Influence of the Spacer Length on the <i>in Vitro</i> Anticancer Activity of Dinuclear Ruthenium−Arene Compounds

Maria‐Grazia Mendoza‐Ferri, Christian G. Hartinger, R. Eichinger et al. · Organometallics · 2008 · 183 citations · Full text

, , +16

Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity

Maria G. Mendoza‐Ferri, Christian G. Hartinger, Marco A. Mendoza et al. · Journal of Medicinal Chemistry · 2009 · 183 citations · Full text

Use of Chelating Ligands to Tune the Reactive Site of Half‐Sandwich Ruthenium(<scp>II</scp>)–Arene Anticancer Complexes

Rafael Fernández, Michael Melchart, Abraha Habtemariam et al. · Chemistry - A European Journal · 2004 · 170 citations · Full text