Spirans XX. Synthesis of 8,8‐dialkylazaspiro[4.5] decanes and 9,9‐dialkylazaspiro[5.5]undecanes

Abstract

Abstract N ‐(2‐Dimethylaminopropyl)‐8,8‐dimethyl‐2‐azaspiro[4.5]decane ( 1 ), N ‐(2‐dimethylaminopropyl)‐8,8‐diethyl‐2‐azaspiro[4.5]decane ( 2 ), N ‐(3‐dimethylaminopropyl)‐9,9‐dimethyl‐3‐azaspiro[5.5]undecane ( 3 ), and N ‐(3‐dimethylaminopropyl)‐9,9‐diethyl‐3‐azaspiro[5.5]undecane ( 4 ) have been synthesized from 4,4‐dimethylcyclohexanone ( 5 ) and 4,4‐diethylcyclohexanone ( 6 ). Biological evaluation of these amines showed significant inhibition of cancer cell growth in human cancer cells grown in tissue culture.