Characteristics of Blood-Brain Barrier to Gamma-Aminobutyric Acid in Neonatal Cat

Abstract

Systemic gamma-aminobutyric acid produces a rapid, sustained, but transiently reversible blockade of evoked axodendritic excitatory postsynaptic potentials in neonatal cortex when the "barrier" operating to restrict its passage has been altered by various experimental procedures. The data obtained under these conditions indicate the existence of well-developed synaptic pathways in the superficial neuropil of immature cortex.