Synthesis and anticancer evaluation of certain α-methylene-γ-(4-substituted phenyl)-γ-butyrolactone bearing thymine, uracil, and 5-bromouracil

Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines

Anne Monks, Dominic A. Scudiero, Philip Skehan et al. · JNCI Journal of the National Cancer Institute · 1991 · 3.3K citations

Medicine, Oncology, Pharmacology +11

Synthesis and Biological Activity of α‐Methylene‐γ‐butyrolactones

H. M. R. Hoffmann, Jürgen P. Rabe · Angewandte Chemie International Edition in English · 1985 · 647 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15

Reactions of Alpha Methylene Lactone Tumor Inhibitors with Model Biological Nucleophiles

S. Morris Kupchan, Dyral C. Fessler, M. Allan Eakin et al. · Science · 1970 · 298 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Total Synthesis of (+)-Cladantholide and (−)-Estafiatin:  5-<i>Exo</i>,7-<i>Endo</i> Radical Cyclization Strategy for the Construction of Guaianolide Skeleton

Eun Lee, Jong Won Lim, Cheol Hwan Yoon et al. · Journal of the American Chemical Society · 1997 · 105 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Antitumor agents. 3. Synthesis and cytotoxic activity of helenalin amine adducts and related derivatives

Kuo‐Hsiung Lee, Hiroshi Furukawa, Eng‐Shang Huang · Journal of Medicinal Chemistry · 1972 · 69 citations

Medicine, Chemistry, Oncology +7