Convenient new synthesis of 1,3-diaroylureas

Abstract

It has been found that symmetrical 1,3-diaroylureas can be prepared in good yields by allowing urea to react with aromatic esters and excess sodium hydride in refluxing 1,2-dimethoxyethane. Applications of this method to the synthesis of unsymmetrical 1,3-diaroylureas and substituted monoaroylureas are also described.