Effect of Acetylsalicylic Acid and Dipyridamole on Platelet Survival and Aggregation in Patients with Atherosclerosis Obliterans

Abstract

The effect of combined treatment with acetylsalicylic acid and dipyridamole on platelet consumption and aggregation was studied in 9 patients with peripheral atherosclerotic disease. The trial was carried out as a randomized double‐blind, cross‐over study. All patients had increased consumption of blood platelets. The treatment produced a marked inhibition of platelet aggregation, increased the bleeding time, but did not reduce the platelet consumption.