Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro

Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Brunangelo Falini, Cristina Mecucci, Enrico Tiacci et al. · New England Journal of Medicine · 2005 · 1.9K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells

Chuanxu Liu, Qianqian Yin, Huchen Zhou et al. · Nature Chemical Biology · 2012 · 223 citations

Life Sciences, Cancer Biology, Molecular Biology +10

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

Guang‐Biao Zhou, Hui Kang, Lan Wang et al. · Blood · 2006 · 197 citations · Full text

Medicine, Oncology, Pharmacology +6

Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin

Hilmar Quentmeier, Maria Paola Martelli, Wilhelm G. Dirks et al. · Leukemia · 2005 · 158 citations · Full text

Life Sciences, Genetics, Molecular Genetics +6

Targeting of AML1-ETO in t(8;21) Leukemia by Oridonin Generates a Tumor Suppressor–Like Protein

Tao Zhen, Chuanfeng Wu, Ping Liu et al. · Science Translational Medicine · 2012 · 97 citations

Medicine, Cancer Biology, Oncology +8