Pharmacokinetics and Dynamics of d-Tubocurarine during Hypothermia in Humans

Abstract

To determine the influence of hypothermia on the pharmacokinetics and dynamics ofd-tubocurarine (dTc), 17 patients were studied during halothane 0.5-0.7 per cent end-tidal and 60 per cent nitrous oxide anesthesia with controlled hyperventilation (PaCO2 ˜ 25 torr) during craniotomy. Ten patients were