Uncatalyzed Three‐Component Synthesis of α‐Hydrazido Phosphonates

Abstract

Abstract Various α‐hydrazido phosphonates have been easily prepared on the basis of the nucleophilic addition of diphenyl phosphite to reactive, preformed N ‐acylhydrazones and a three‐component (aldehydes, N ‐benzoylhydrazide and diphenyl phosphite) coupling reaction through a non‐catalyzed process. An unprecedented and promising enantioselective example of this reaction is also reported.