Bioinspired and Concise Synthesis of (±)‐Stemoamide

Abstract

Natural inspiration: A concise total synthesis of (±)-stemoamide was completed in eight steps with a 37 % overall yield. A bioinspired N-acyliminium ion cyclization and an unprecedented dynamic ruthenium-catalyzed cyclocarbonylation ensured the high efficiency of the synthesis. A novel silver-mediated cyclization of an allenic alcohol shows potential for the future asymmetric synthesis of the target. TMS=trimethylsilyl. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.