Chronopharmacokinetics of nicotine*

Abstract

The estimated circadian(t) showed a maximum at approximately 11 AM and a flat minimum from 6 PM to 3 AM; the estimated meal(t) showed a sharp increase up to 1 hour (after the meal), at which point clearance is increased 42%, and a slower decrease thereafter, returning to baseline (zero) after 2.8 hours. Individual estimates of baseline clearance are found to have a linear relationship with body weight. No other covariate, sex in particular, effect could be found.