Should morbidity replace mortality as an endpoint for clinical trials in intensive care?

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

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Medicine, Pharmacology, Pharmacotherapy +16

A New Measure of Health Status for Clinical Trials in Inflammatory Bowel Disease

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Medicine, Clinical Sciences, Internal Medicine +13

Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction

Joseph Lau, Elliott M. Antman, Jeanette Jimenez-Silva et al. · New England Journal of Medicine · 1992 · 1.2K citations · Full text

Medicine, Biostatistics, Cardiology +16

A new measure of health status for clinical trials in inflammatory bowel disease

Gordon Guyatt, Alba Mitchell, E. Jan Irvine et al. · Gastroenterology · 1989 · 736 citations · Full text

Medicine, Clinical Sciences, Internal Medicine +13

Efficacy of antibiotic prophylaxis for prevention of native-valve endocarditis

Jan T. M. van der Meer, Jan T. M. van der Meer, Marc Michel et al. · The Lancet · 1992 · 347 citations

Medicine, Cardiology, Infectious Diseases +14