Association Analysis of<i>CYP2A6</i>Genotypes and Haplotypes with 5-Fluorouracil Formation from Tegafur in Human Liver Microsomes

Abstract

We concluded that CYP2A6*4 and the novel CYP2A6*1B variant were the major genetic determinants of interindividual variability in 5-FU formation from tegafur in Chinese livers. Original submitted 2 November 2010; Revision submitted 3 December 2010.