A superactive antinociceptive pentapeptide, (D‐Met²,Pro⁵)‐enkephalinamide

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates

JEAN M. HAMBROOK, Barry A. Morgan, Michael J. Rance et al. · Nature · 1976 · 517 citations

Life Sciences, Neurobiology, Neuroscience +5

[D-Ala ² ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic

Candace B. Pert, Agu Pert, Jaw‐Kang Chang et al. · Science · 1976 · 468 citations

Medicine, Neuroscience, Pharmacology +12

β-Endorphin as a potent analgesic by intravenous injection

LIANG‐FU TSENG, Horace H. Loh, Choh Hao Li · Nature · 1976 · 281 citations

Medicine, Pharmacology, Pain Management +10

Comparative study on analgesic effect of Met5-enkephalin and related lipotropin fragments

L. Gráf, József I. Székely, András Z. Rónai et al. · Nature · 1976 · 147 citations

Medicine, Pharmacology, Pharmacotherapy +13