Enhanced expression of proproliferative and antiapoptotic genes in ulcerative colitis-associated neoplasia

Abstract

These results suggest that telomerase and ILK activation occurs during the later stages of carcinoma progression, whereas upregulation of survivin, c-MYB, and Tcf-4 is a feature of the early stage of development of neoplasia, and thus, they might serve as early indicators for UC-associated colorectal carcinogenesis.